What things make the tele sound different to the strat?

they have different pick ups, I have a Strat and i like the nice clean sound you get from them them, i think Telecasters have hum buckers, which are better if you want a distorted/overdrive sound. Also the neck and body shape and type of wood make a big difference in the sound of a guitar, but mostly it comes from the pick ups and the amp and other equipment you are using